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The film takes place over the course of a year, with the primary focus being on a struggling comedy writer and improv comedian named David (Plemmons), returning to his hometown of Sacramento from New York to look after the needs of his terminally ill mother, Joanne (Shannon), uncomfortably reuniting with his mostly estranged father, Norman (Whitford), who has yet to fully accept him since coming out, and two mostly annoying younger sisters. The family is preparing for the inevitable life after Joanne, as she has decided to forego additional grueling chemo treatments and accept her fate with the cancer that is overtaking her. While there, David also begins to find some healing time with dormant familial relationships and a bit of perspective on the other trials and tribulations in his personal, professional and romantic life.