A series of nuclear explosions in the South Pacific creates a titanic lizard monster that’s born pregnant and destroys Manhattan. With over 200 eggs laid, the human race faces extinction if a biologist (Matthew Broderick), a couple of reporters, the French CIA, and the military can’t kill them all before they all lay eggs of their own.
Eco-terrorist Alan Jonah (Charles Dance), who has taken as hostage a paleobiologist under the employ of the Titan-research group known as Monarch, Dr. Emma Russell (Vera Farmiga), along with her teenage daughter Madison (Millie Bobby Brown), to utilize Orca, an experimental mind-control technology she created to try to control the Titans, the giant monsters of the Earth that he sees as protecting the planet from humanity’s continued exploitation and destruction, effectively by destroying most of human civilization as we know it. Emma’s estranged husband Mark, who is trying to get his life back together after losing his son in the wake of Godzilla’s 2014 rampage, is out to find them and save them from further efforts to destroy the world, or themselves. Mark soon hooks up with Emma’s team of scientists at Monarch, as well as members of the military, to try to find a way to thwart Jonah’s plans and to keep the escalating numbers of monsters, led by the invasive three-headed alpha Titan named King Ghidorah, from destroying everything we hold dear. Godzilla may be their last line of defense, but where is he?